Endocrine Abstracts

In utero exposure to maternal obesity programs an increased risk of obesity. Animal models have shown that offspring obesity is often preceded by increased food intake, however, the mechanisms that mediate these changes are not understood. Using a mouse model of maternal diet-induced obesity we observed increased intake specifically of a high-fat pellet in adult offspring of obese mothers. Through small RNA sequencing, we identified programmed overexpression of miR-505-5p in t...

In liver, melatonin (Mel) and glucocorticoids (GC) influence the systemic energy homeostasis. Animals without pineal gland present impairment in glycemic control, as in type-2 diabetes. In turn, Mel reduces the GC levels, particularly in nocturnal animals. We aimed to evaluate the influence of Mel, as well as GC receptor blockade by RU486 treatment on hepatic and pancreatic energy metabolism. Male Wistar rats were subjected to surgical removal of pineal and, 25 days after the ...